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Pharmacol Ther 239: 108277

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(PubMed) Ames BN, Elson-Schwab I, Silver EA

Here, we review the pathophysiology and treatment of T2D, the many mechanisms of action of the GLP-1 receptor agonists, and their efficacy as T2D and obesity treatments

11 Clinical Trials on Triple GLP-1/GIP/Glucagon Agonists Retatrutide: A Triple Agonist for Maximum Weight Loss Retatrutide (LY3437943) is a triple incretin receptor agonist targeting the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors, and is designed to maximize weight loss and metabolic improvement through complementary hormonal pathways