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The body synthesizes glutathione from three amino acids glutamine, cysteine, and glycine
Farr 2001, p
Treatment is limited for most IEMs and is often based on reducing the accumulation of toxic metabolites through substrate restricted diets, cofactor supplementation, specific therapies to facilitate urinary excretion and enzyme replacement
However, this process must carefully navigate ethical concerns and the risks associated with invasive interfaces, integrating imaging, AI, and the surgeon interface to ensure safety and ethical compliance in clinical practice ( 5.3 System engineering and standardization To meet the practical needs of intraoperative applications, a three-step translation roadmap can be outlined
& Jakobsson, P
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