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Glutathione may also affect the levels of reactive oxygen species (ROS) and thus participate in the hypersensitive reaction launched by resistant plants following pathogen attack 4,18

However, these resulting effects of NRF2 induction via CDDO treatment were to a dramatically lower degree compared to the effects of NRF2 induction upon GSH depletion in Gclc L-KO mice (Figs

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Staggered administration by 68 hours minimizes peak plasma concentration overlap and reduces the likelihood of acute receptor saturation