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Alternatively, your individual response may require higher doses
for example, NTS PrRP neurons are leptin sensitive in rats but not in mice (61)
For detailed strategies, see our [guide to preventing muscle loss on GLP-1 medications](/guides/glp1-muscle-loss-prevention-semaglutide-tirzepatide-guide)
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That combination is likely why retatrutide's trial results have outperformed every approved weight loss drug on the market
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