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Common causes include puberty, aging, anabolic steroid use, certain prescription medications, marijuana use, obesity, and underlying medical conditions

While some users report benefits within weeks, others require longer timeframes or experience no noticeable changes

Other factors (e.g., hormonal contraception or replacement therapy, smoking, and long-distance travel) should be considered as potential exclusion criteria

The "LR3" modification (a substitution at position 3 and an arginine extension) reduces IGF-1 LR3's affinity for IGF-binding proteins (IGFBPs)

Time-course studies demonstrate sustained receptor activation over extended incubation periods