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GLP-1 receptor activation preserves cardiac performance by activating multiple pro-survival kinases and modulating cell apoptosis and energy utilization (5-7), and exendin-4 (a long-acting GLP-1 analogue)-mediated GLP-1 receptor activation in models of MI inhibits cardiac remodeling by mitigating oxidative stress-induced injury (6) and attenuating interstitial fibrosis (4)
( Related : 5 Ways to Break a Weight Loss Plateau That Actually Work) Non-response Then there are patients who may not experience any meaningful weight loss despite consistent use
Average weight loss was ( 7.8 pounds (3.55 kg) for a 3.75/23 mg (phentermine/topiramate) dose 16 pounds (7.27 kg) for a 7.5/46 mg dose 18 pounds (8.25 kg) for a 15/92 mg dose In users of phentermine-topiramate, weight loss translated to a significant decrease in waist circumference as well as improved insulin sensitivity, improved blood sugar management, and reduction in blood pressure ( May be helpful for certain eating disorders The combination of phentermine and topiramate may help reduce binge eating in people with BED and bulimia nervosa
These include: Renal impairment impaired kidneys cannot clear excess magnesium and other minerals safely G6PD deficiency high-dose vitamin C can trigger haemolytic anaemia in these patients Congestive heart failure fluid overload risk with IV administration
So swapping refined carbs for wholegrain options reduces cravings and stabilises blood sugar
