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The existing amylin analogue pramlintide (sold as Symlin in the US for diabetes management) requires multiple daily injections

It is a 39-amino acid synthetic peptide that targets both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor simultaneously

This suggests enhanced lipolytic sensitivity under chronic treatment

SGLT2 inhibitors block the reabsorption of glucose in the kidney, increase glucose excretion, and lower blood glucose levels