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The fast, large liver-fat reductions and the rise in fat-oxidation markers like beta-hydroxybutyrate point to a genuine metabolic effect beyond simple eating less

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However, most available evidence comes primarily from preclinical and early translational studies, and the long-term safety, interindividual variability, and reproducibility of clinical outcomes still require thorough evaluation

Gene Activation: MC1R activation initiates a signaling cascade (cAMP production $\rightarrow$ MITF expression) that induces the enzymes (tyrosinase) necessary for eumelanin production