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How Tirzepatide Compares to Semaglutide Both drugs fall under the GLP-1 agonist category, and semaglutide (Ozempic, Wegovy) has also shown benefits for weight loss and glycemic control
it is physiological: brain circuits that defended a higher body fat set point reassert themselves, promoting stronger hunger, food-seeking, and carbohydrate preference until energy balance is restored
10.1021/acsomega.3c08968 20 DuS.ChenX.RenR.LiL.ZhangB.WangQ.et al (2024)
Participants who achieved prediabetes remission without losing weight had a ~71% lower risk of developing T2D over ~10 years
GLP1RAs have been available internationally and are recommended when treatment escalation for type 2 diabetes is required after metformin and lifestyle management
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