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In the Phase 3 TRIUMPH-4 trial, a new safety signal called dysesthesia (abnormal skin sensations like tingling or burning) appeared in up to 20.9% of patients on the highest dose
While aluminum oxide/silicon carbide (Al 2 O 3 /SiC) and silicon nitride/silicon carbide (Si 3 N 4 /SiC) ceramic nanocomposites have received the greatest attention, other phases like titanium nitride (TiN), titanium carbide (TiC), titanium dioxide (TiO 2 ), zirconium dioxide (ZrO 2 ), chromium carbide (Cr 3 C 2 ), and yttrium aluminum garnet (YAG) can also be used as nanoreinforcements
3 But biotechnology and pharmaceutical companies dont have to navigate the drug development journey alone
This is important because it suggests the anti-psoriatic activity can be localized to a specific portion of the larger protein, potentially allowing the development of small, targeted peptide therapeutics
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