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HendersonSJKonkarAHornigoldDCTrevaskisJLJacksonRFritsch FredinMet al

Thus, preference should be given to molecules with the highest potency, such as semaglutide and dulaglutide, over those with lower potency, like exenatide

While a 5% weight reduction is commonly considered clinically meaningful at the individual level [33], smaller differences between treatments (e.g., 2%) are unlikely to translate into meaningful differences in clinical decision-making and are therefore appropriate for defining equivalence

Both medications can help reduce hunger, improve feelings of fullness, and support long-term weight loss, but individual results, side effects, and treatment suitability can vary

After accounting for the results from the interim analysis, the nominal two-sided significance level for the primary outcome was 0.04561