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Am J Hum Genet

While the exact mechanisms continue to be studied, the practical implication is clear: Retatrutide users appear to lose fat preferentially while protecting muscle tissue

Yes, you will lose some muscle mass on GLP-1 medications

An older patient losing 15kg may show better HbA1c and liver enzymes while simultaneously crossing into sarcopenic obesity worse functional outcomes despite "better" numbers

The further impact of miR-133a on osteosarcoma progression in vivo strongly encourages further studies to evaluate whether it could be a new prognostic biomarker and a possible anti-metastatic target for osteosarcoma treatment