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Given the low, single-digit penetration of pumps in the T2D intensive insulin therapy population, the potential impact to the insulin pump [total addressable market] looks relatively minor to us. Despite exuding positivity around GLP-1s, Hamdy sees no impact on type 1 diabetes insulin requirements
However, some scholars have proposed that the effect of GLP-1 in the liver is indirectly mediated by multiple mechanisms, such as reducing fat absorption or inhibiting fat cells through acyl-CoA synthetase long chain family member 1 (ACSL1), CCAAT/enhancer binding protein (C/EBP), peroxisome proliferator-activated receptor- (PPAR), and sterol regulatory element binding protein-1c (SREBP-1c) pathways to achieve the purpose of reducing liver lipids [38]
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