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[5] [10] It works by mimicking the action of the naturally occurring GLP-1 hormone, which stimulates insulin secretion in response to food intake, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways

However, as weight loss progresses, some patients require dose adjustments to ACE inhibitors, ARBs, or other antihypertensives to avoid hypotension

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