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Statistical analysis was performed using Metaboanalyst 6.0 ( and a heatmap showing the relative intensity of compounds in the various samples was generated

Chronic administration of high doses of oral levocarnitine in patients with severely compromised renal function or in ESRD patients on dialysis may result in accumulation of the potentially toxic metabolites, trimethylamine (TMA) and trimethylamine-N-oxide (TMAO), since these metabolites are normally excreted in the urine

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Simic, D., Harmer, A

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