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Regulatory approval status Cagrilintide is not currently FDA-approved as a standalone medication

However, individuals with a history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, pancreatitis, or severe gastrointestinal disorders should discuss alternative therapies with their provider

If the intervals between shots are long enough, this can cause some weight regain, which can be very frustrating for patients, says Meghan Garcia-Webb, MD, a board-certified internal, lifestyle, and obesity medicine physician in private practice in Wellesley, Massachusetts

PMID 11121126

Retatrutides Phase 2 data suggests the pattern continues with triple receptor activation