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Description

While early attempts to target HGF with antibodies such as rilotumumab yielded disappointing results in broader MET-positive populations in the RILOMET-1 trial (HR = 1.34, P = 0.003), 395 selective MET TKIs have shown promise, particularly in tumors with MET gene amplification

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Sulforaphane activates a lysosome-dependent transcriptional program to mitigate oxidative stress

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Hou, J., Hsu, J.-M

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Most protocols are cycled: 5-6 months on, 1-2 months off to allow the pituitary to reset

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