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Among them, SOD is an important antioxidant enzyme class that exclusively defends against excessive O2- during metabolic processes in the organism, and its activity level indirectly reflects the degree of oxidative damage suffered by the organism (Liu et al., 2019), but the highest concentrations are found in the liver, biliary epithelium and bone (Peng et al., 2015), the enzyme levels of AKP and ACP are greatly increased (Shang et al., 2003)

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Activation of MET promotes resistance to sorafenib in hepatocellular carcinoma cells via the AKT/ERK1/2-EGR1 pathway