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Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-proteincoupled receptor FFAR2
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Overall, GLP-1RAs provide a highly effective and well-tolerated treatment option to help individuals with obesity achieve and maintain body weight reductions of 510%, thereby improving weight-related complications in addition to weight loss
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Although bariatric surgery can lead to weight loss of at least 25% and long-term weight maintenance, it is not scalable at the population level, and many people are still afraid to have surgery because of the possibility of complications, [135, 136]
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