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They arent necessarily bad in fact, we need them for signaling and immune defense but the problem is when there are too many free radicals, causing an imbalance called oxidative stress. Vitamin C is also excellent at supporting the body's regeneration of vitamin E and glutathione, which are key components of the antioxidant network
It also reframes the whole question
Circulating protein levels of insulin-like growth factor 1 signaling pathway and the predisposition to colorectal carcinogenesis: a systematic review and meta-analysis
Ishihara, et al., Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures
Repeated dehydration may even contribute to permanent kidney damage
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