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Reuben A, Zhang J, Gittelman R, Chiou SH, Li J, Fujimoto J, Behrens C, Kheradmand F, Chow CW, Bernatchez C, Eterovic AK, Benzeno S, Vignali M, Wu X, Ye Y, Cascone T, Rerbst R, Swisher SG , Kadara H, Moran C, Zhang J, Scheet P, Vaporciyan A, Sepesi B, Gibbons D, Robins H, Hwu P, Heymach J, Sharma P, Allison J, Lee J, Davis M, Wistuba I, Futreal A, Zhang J

The technology enables precise genome modification through targeted DNA cleavage followed by endogenous repair mechanisms, facilitating gene knockout, insertion, or sequence alteration