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Robertson FG, Harris J, Naylor MJ, Oakes SR, Kindblom J, Dillner K, et al
Some research protocols have explored doses up to 4.5 mg weekly, which showed slightly greater efficacy in the phase 2 dose-finding trial but also increased side effect burden
A: The shift is gradual
The primary endpoint, change of weight loss over time, was analyzed by repeated-measures ANOVA comparing patients with GLP-1-RAs plus usual care weight management (GLP-1-RA group) to patients with usual care weight management only (UCWM)
The overall risk in terms of how many patients are potentially affected is still very small, he notes
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