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Elevated plasma LPS and LBP levels are associated with disease severity and increased systemic cytokine levels, whereas dysregulation of the tryptophan-kynurenine pathway leads to the production of neurotoxic metabolites that exacerbate inflammation [70]
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Lack of B12 can affect immune system
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For the reconstitution step itself drawing the BAC water and adding it to the vial use a larger 35 mL syringe with a 2327 gauge needle
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