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Important Considerations Individual Variation: L-cell density and function vary significantly between individuals based on genetics, age, gut health history, and metabolic status

Statements Author contributions KY: Conceptualization, Writing original draft, Writing review & editing

Further studies in pigs revealed that a high degree of NH2-terminal degradation of GLP-1 occured in the hepatic portal system (34), concomitant with the evidence that DPP-4 is found in high concentrations in hepatocytes and endothelial cells (35, 36)

Cons: Cost: Often more expensive than standard supplements

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