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In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected

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Elevated homocysteine levels are associated with increased risk of heart attack, stroke or dementia

Animal acute toxicity studies across Sikiric's group publications have consistently shown a low acute toxicity profile, with no defined lethal dose identified in standard rodent models