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We calculated Pearsons correlation coefficient to assess correlations between significant GPs (i.e., GPs that showed significant fold changes at the end of 4th week during 4-week intermittent fasting and 1 week after 4-week intermittent fasting) and the components of metabolic syndrome, lipid panel, hepatic panel, and adiposity, oxidative stress, and inflammation biomarkers

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IGF-1 LR3 has been used extensively in this context precisely because its extended half-life allows sustained receptor activation in cell culture and in vivo models without the impractical dosing frequency that native IGF-1 would require

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