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Tier 1: High cramp-amplification risk (address first) Loop diuretics (furosemide, bumetanide): recheck potassium and magnesium within 2 weeks of GLP-1 initiation Thiazide diuretics (HCTZ, chlorthalidone): consider potassium-sparing alternatives if cramping persists PPIs at doses above standard (e.g., omeprazole 40 mg daily): check serum magnesium, consider step-down Tier 2: Moderate cramp-amplification risk (monitor) Statins: obtain baseline CK if cramps are new

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Its a tiny but powerful and abundant protein compound made up of three amino acids