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Investigating the interaction of these nanocarriers with the TME and their long-term safety profiles will be crucial for translating these findings into clinical applications
Mitochondrial dysfunction is recognized as one of the primary hallmarks of biological aging, and MOTS-c directly addresses this mechanism
In addition to these widely used AOMs, Exenatide, one of the earliest GLP-1 RAs approved by the FDA and EMA for T2DM management, is not indicated for weight management but remains clinically relevant, particularly in older adults with comorbid obesity and T2DM, given its long-term clinical experience and established tolerability profile [26,27,28]
Add in the potential risks, and its just not worth it
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