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Tirzepatide initially causes nausea, vomiting, or mild diarrhea in some patients during the first weeks of treatment

doi:10.1007/s13300-011-0002-3 Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W

As the IAM can react with the free thiols remaining on the carbonylated sites, the carbonyl modifications 5 derivatized with Ao-C3-thiol-IAM were implemented for the database search

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GLP-1 is also believed to participate in weight loss after bariatric surgery which brings food more rapidly into the distal small intestine