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Molecular enzymology of carnitine transfer and transport

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In laboratory settings, it is often used to observe how prolonged pathway activation influences cellular signaling flow, nutrient utilization patterns, and downstream growth-related pathways

Dogan ADA, Hess S, Jensen TT, Bladbjerg E-M, Juhl CB, Hilberg O

Furthermore, since the instability of Ala 2 is caused by degradation of DPP-4, Ala 2 may not need to be changed if the peptide is fused with albumin or Fc domain (discussed later) for long-term activity, which creates a steric hindrance to prevent the enzyme from getting close