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Early human trials with single subcutaneous doses of SAR441255 in healthy subjects demonstrated improved glycemic control during a mixed-meal tolerance test, while also being well-tolerated

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Both glucose and sodium ions bind to the cotransport protein, with the Na + electrochemical gradient, maintained by the basolateral sodiumpotassium adenosine triphosphatase, driving glucose uptake across the luminal membrane ( Figure 1 )

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