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Semaglutide possesses a well-established cardioprotective profile, supported by landmark trials (SUSTAIN-6, PIONEER-6, and SELECT) that demonstrate significant reductions in MACE ( For tirzepatide, the SURPASS-CVOT trial provides robust contextual cardiovascular outcome data
P., Waterman, M
This class can increase glucose-dependent insulin release, reduce glucagon when glucose is high, slow stomach emptying, and support fullness after eating
Risk of orthostatic hypotension associated with sodium-glucose cotransporter-2 inhibitor treatment: a meta-analysis of randomized controlled trials
& Hua, X
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