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Lixisentaide is a GLP-1 drug that was approved in the United States in 2016 and discontinued by its manufacturer (Sanofi) in 2023
Tirzepatide may be better for patients who have not seen success with other programs, who have insulin resistance, or who want to pursue more aggressive weight loss goals
The starting conformations were obtained by manually binding GS(H) to a snapshot of the MD simulation of TRaQ-G and the crystal structure of MeTRaQ-G, respectively
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