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With that diagnosis, people with T1D are also lacking many other hormones related to fullness, insulin sensitivity and weight control, including: amylin, glucagon, pancreatic polypeptide, somatostatin and ghrelin

The present findings are supported by the results of the SECRET trial, which showed that non-pharmacologic body weight reduction achieved through caloric restriction improved exercise capacity in patients with the obesity phenotype of HFpEF 15

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However, human safety data remains limited to anecdotal reports and Phase I/II trial abstracts that never reached full peer-reviewed publication