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Description

Recent studies of isolated L-cells (95) and a L-cell derived cell line, GLUTag cells, have shown stimulation of GLP-1 secretion by glucose acting to inhibit K+ channels as in islet beta cells, by activation of the SGLT-1 transporter leading to depolarization (91), or activation of sweet taste receptors (T1R2 / T1R3) which activate Gq and PLC

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Furthermore, cellular antioxidant capability is also decreased by suppressed GPx4 expression (e.g., RSL3), which results in lipid peroxidation and ferroptosis [76]

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