Common research protocols cited in the peptide community use 1 to 2 mg, 3 to 5 times weekly, over 8 to 12-week cycles
doi: 10.1016/J.CARBPOL.2022.120392 75 HuanY.KongQ.MouH.YiH
Cognitive Decline and Neurodegenerative Conditions Cognitive decline and neurodegenerative conditions show substantial preclinical evidence across multiple pathologies: Stroke models: BPC-157 given during reperfusion counteracted neuronal damage and produced full functional recovery in spatial memory, motor coordination, and balance tests Parkinsons models: MPTP-induced models showed reduced motor symptoms (tremor, rigidity, akinesia), protection of nigrostriatal dopaminergic neurons, and near-complete prevention of mortality Multiple sclerosis models: Cuprizone-induced demyelination resulted in significantly less brain damage and reduced clinical abnormalities when BPC-157 was given in drinking water or intragastrically Traumatic brain injury: Falling weight model studies demonstrated reduced hemorrhage, decreased brain lacerations and edema, and improved early outcomes These diverse models share common mechanisms
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Discussion 1) The study by Tukhovskaya et al investigated the impact of intranasal DSIP on motor function recovery and brain infarction volume in SD rats subjected to focal stroke induced by MCAO
