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A mechanism of action phase 1 study showed that the glycemic efficacy of tirzepatide in T2DM results from concurrent improvements in key components of diabetes pathophysiology, including -cell function, insulin sensitivity, and glucagon secretion (135)
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pH profiles indicative of rate-limiting nucleophilic displacement in thioltransferase catalysis
Lastly, due to its rarity, MTC cells were not used, so findings may not apply beyond PTC
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