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In summary, GIP influences bone remodeling through an entero-endocrine-osseous axis and plays a role in coordinating optimal bone turnover in response to food intake, mainly during the day

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Other randomized clinical trials, whose main objective was to reduce macro and microvascular outcomes, were conducted, such as the ACCORD study (Action to Control Cardiovascular Risk in Diabetes) [38], ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) [39] and the VADT (Veterans Affair Diabetes Trial) [40]

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A.SynenkiL.ZirkA.EisenbartJ.et al (2013)