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Lesions may be limited to small foci but may occupy large interconnecting areas of a lobe without markedly disturbing the lobe outline

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For example, a positive thyroid hormone response element has been discovered in the promoter region of hCS, and maternal thyroid hormone appears to up-regulate hCS gene expression by trophoblast cells.110 Interleukin (IL)-1, IL-6, and 1,25-dihydroxyvitamin D are synthesized and secreted by the syncytiotrophoblast, and each of these factors stimulates the synthesis of hCS by trophoblast cells.104 Thyroid hormone and vitamin D stimulate hCS gene expression by the binding of thyroid hormone receptor and vitamin D receptor, respectively, to the composite nuclear hormone receptor site on the hCS promoter.125 The action of IL-6 is mediated by the transcription factor NF-IL6, which binds to three consensus NF-IL6 elements in the hCS promoter.104, 113, 126 Fig

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These samples were then distributed into five experimental groups: control (no LC), and LC additions from different stock solutions (25, 50, 250, and 500 mM), resulting in final concentrations of 0.5, 1-, 5-, and 10-mM LC, respectively