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Some peptides occur naturally, regulating everyday functions like appetite, digestion, and metabolism, while others are synthesized to mimic or amplify those same natural signals
Several GLP-1RAs, including exenatide, dulaglutide, semaglutide, and liraglutide, are approved for T2D, alongside tirzepatide, which also acts on glucose-dependent insulinotropic polypeptide (GIP) receptors
Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite are typical adverse reactions
In the transcription factor pathway, H 2 O 2 regulates the activity of transcription factors, including NF-B, AP-1, HIF-1, and FOXO3 [82, 83], altering gene expression and promoting apoptosis