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Wegovy is also available on the NHS through Tier 3 specialist weight management services under NICE TA875, at BMI 35 with at least one comorbidity, capped at two years per course 7

58 Blocking IL-23 may thus eventually reduce bone loss and osteoproliferation, a typical feature of psoriatic arthritis

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There is growing evidence that the microbiome may be critical for establishing, maintaining, and reversing obesity 14,15,16 , and that both diet composition and adiposity each contribute to modulation of the mouse gut microbiome profile 49