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Retatrutide, a triple agonist in Phase 3 clinical trials, produced average weight loss of 24 percent at 48 weeks in Phase 2 data (Jastreboff et al., NEJM , 2023)

Patients with diabetes were excluded

Reclassification is not supposed to be a route for unapproved drugs to get into the market, Janet Woodcock, a former FDA chief deputy commissioner who helped oversee the 2023 assignment of the peptides to category two due to safety concerns, told ProPublica before the meeting