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Epub 2016 Jun 4

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In cases of documented vitamin deficiency, the regimen could be an initial intensive phase (like 2 mL IM three times a week for 2 weeks) followed by reevaluation

Gene expression analysis revealed Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased 2.1-foldall statistically significant changes indicating re-entrainment of disrupted circadian oscillations