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176 Collectively, these advances underscore a fundamental conceptual shift: proteostasis must now be viewed not as a collection of isolated degradation mechanisms but as a coherent, adaptive, and deeply integrated cellular defense network whose resilience determines disease trajectory

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To reconstitute, direct the diluent down the inner wall of the vial rather than onto the peptide cake, swirl gently to dissolve, then characterize the reconstituted material analytically before using it as a comparator in further research

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