Both medications act on GLP-1 receptors, but tirzepatide also activates GIP receptors, giving it a dual mechanism that semaglutide lacks
While GLP-1 primarily mediates glucose-dependent insulin secretion and appetite suppression, GIP influences insulin secretion and, based on preclinical studies, may affect lipid metabolism and other metabolic pathways
Reproductive system and breast disorders were the second most commonly reported AEs by organ class, reported in 68% (17/25) of subjects (Table 6), of which vaginal haemorrhaging was the most common event, occurring in 64% (16/25) of subjects
Moreover, the combined effect of GLP-1RAs with other molecules may vary depending on sex
Additionally, they are seeking foods with added functional benefits such as fiber and vitamins, and pre-packaged foods that offer smaller portions