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Tirzepatide demonstrated a 94% reduction in progression from prediabetes to diabetes in the SURMOUNT trials, the most effective diabetes prevention ever documented in clinical research

J Res Health Sci

Proposed benefits: Promotes cell migration, angiogenesis (new blood vessel growth), and tissue regeneration

These effects were more noticeable in longer trials and when ALA was combined with dietary changes.29 A 2020 dose-response meta-analysis confirmed small but statistically significant reductions in weight and BMI across 18+ randomized controlled trials.30 However, waist circumference (WC) a marker of central obesity showed no consistent change, and the benefit appeared greater in women and with longer treatment durations