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Clinicians typically consider switching to maintenance when a patient has reached approximately 70 to 90 percent of their target weight loss, has maintained a stable weight for 4 to 6 weeks, and has established healthy habits over a 6- to 12-month period

Most investigators specialized in endocrinology and internal medicine, with others specializing in family medicine, psychiatry and clinical psychology

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Studies with mouse models have shown that hepsin is important for maintaining hepatic structural homeostasis, liver metabolism, and adipocyte browning (Hsu et al

Shi Y, Cui Y, Sun X, et al