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Tesamorelin elevates IGF-1, and this elevation must remain within normal physiological range (roughly 100 to 300 ng/mL depending on age)
I find the risk-benefit calculation here overwhelmingly favorable for most people
Through the above mechanisms, GLP-1RAs can mediate the function of regulating endothelial-mediated contraction and vasodilation, as well as maintaining the stability of the endothelial barrier
These include: Nausea particularly during dose escalation Vomiting Diarrhoea Constipation Decreased appetite These effects were generally mild to moderate in severity and tended to diminish over time as the body adjusted to the medication
Appetite suppression from the GLP-1 and GIP components appears well-maintained with microdosing, particularly at twice-weekly frequency
