However, berberine doesnt lower blood glucose by increasing GLP-1 in the body
00:06:42 Vickie Danaher So generally speaking, efficacy seems pretty similar if we think about 9% more weight loss than placebo versus 11% more weight loss than with placebo, with oral semaglutide potentially having a very slight edge
Nassif M.E., Windsor S.L., Borlaug B.A., et al
At excessive doses, this effect intensifies to the point where even small sips of water come back up
In a randomized, placebo-controlled study, pemvidutide, a dual GLP-1/GCG receptor agonist, significantly decreased liver fat content by up to 68.5% after 12 weeks of treatment, accompanied by reductions in hepatic inflammation markers and body weight, highlighting the potential of dual receptor agonists to modify MASLD pathophysiology (47)