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from a systems-neuroscience perspective, the earliest failure is not metabolic in isolation but a collapse of precision control- the brains ability to assign reliable confidence to prediction errors across hierarchical levels
Some patients start at 18.75 mg and titrate up
Diabetes, Obesity & Metabolism, 20 ,
A lower ratio may even be indicative of neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease
She explains that the medication dosage and the amount of alcohol involved are important factors
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